Chiara, Federica <br/><br/>
A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity.  [electronic resource] 

 -  The Journal of biological chemistry  Oct 2004 
 - 42516-27 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0021-9258 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M406051200  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Actins--metabolism<br/>Animals<br/>Apoptosis<br/>Asparagine--chemistry<br/>Aspartic Acid--chemistry<br/>Becaplermin<br/>Binding Sites<br/>COS Cells<br/>Cells, Cultured<br/>Dose-Response Relationship, Drug<br/>Enzyme Activation<br/>Fibroblasts--metabolism<br/>Flow Cytometry<br/>Genetic Vectors<br/>Humans<br/>Kinetics<br/>Mice<br/>Mice, Inbred C57BL<br/>Mice, Mutant Strains<br/>Mitogen-Activated Protein Kinase 1--metabolism<br/>Mitogen-Activated Protein Kinase 3--metabolism<br/>Mutation<br/>NIH 3T3 Cells<br/>Phosphatidylinositol 3-Kinases--metabolism<br/>Platelet-Derived Growth Factor--metabolism<br/>Point Mutation<br/>Protein Serine-Threonine Kinases--metabolism<br/>Protein Structure, Tertiary<br/>Proto-Oncogene Proteins--metabolism<br/>Proto-Oncogene Proteins c-akt<br/>Proto-Oncogene Proteins c-sis<br/>Receptor, Platelet-Derived Growth Factor beta--genetics<br/>Signal Transduction<br/>Substrate Specificity<br/>Time Factors<br/>Tyrosine--chemistry<br/>Up-Regulation<br/>Wound Healing