TY - GEN AU - Priest,Birgit T AU - Garcia,Maria L AU - Middleton,Richard E AU - Brochu,Richard M AU - Clark,Samantha AU - Dai,Ge AU - Dick,Ivy E AU - Felix,John P AU - Liu,Chou J AU - Reiseter,Brita S AU - Schmalhofer,William A AU - Shao,Pengcheng P AU - Tang,Yui S AU - Chou,Margaret Z AU - Kohler,Martin G AU - Smith,McHardy M AU - Warren,Vivien A AU - Williams,Brande S AU - Cohen,Charles J AU - Martin,William J AU - Meinke,Peter T AU - Parsons,William H AU - Wafford,Keith A AU - Kaczorowski,Gregory J TI - A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model SN - 0006-2960 PY - 2004///0924 KW - Amides KW - chemical synthesis KW - Analgesics KW - Animals KW - Binding Sites KW - Biphenyl Compounds KW - Brain KW - metabolism KW - Cell Line KW - Disease Models, Animal KW - Formaldehyde KW - administration & dosage KW - Ganglia, Spinal KW - drug effects KW - Humans KW - Mice KW - Muscle Proteins KW - biosynthesis KW - NAV1.2 Voltage-Gated Sodium Channel KW - NAV1.5 Voltage-Gated Sodium Channel KW - NAV1.7 Voltage-Gated Sodium Channel KW - Nerve Tissue Proteins KW - antagonists & inhibitors KW - Pain Measurement KW - Patch-Clamp Techniques KW - Rats KW - Recombinant Proteins KW - Sodium Channel Blockers KW - Sodium Channels KW - Succinates KW - Synaptosomes KW - Tetrodotoxin N1 - Publication Type: Journal Article UR - https://doi.org/10.1021/bi0493259 ER -