Priest, Birgit T <br/><br/>
A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.  [electronic resource] 

 -  Biochemistry  Aug 2004 
 - 9866-76 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0006-2960 
<br/><br/><label>Standard No.: </label>10.1021/bi0493259  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amides--chemical synthesis<br/>Analgesics--chemical synthesis<br/>Animals<br/>Binding Sites<br/>Biphenyl Compounds--chemical synthesis<br/>Brain--metabolism<br/>Cell Line<br/>Disease Models, Animal<br/>Formaldehyde--administration & dosage<br/>Ganglia, Spinal--drug effects<br/>Humans<br/>Mice<br/>Muscle Proteins--biosynthesis<br/>NAV1.2 Voltage-Gated Sodium Channel<br/>NAV1.5 Voltage-Gated Sodium Channel<br/>NAV1.7 Voltage-Gated Sodium Channel<br/>Nerve Tissue Proteins--antagonists & inhibitors<br/>Pain Measurement--drug effects<br/>Patch-Clamp Techniques<br/>Rats<br/>Recombinant Proteins--antagonists & inhibitors<br/>Sodium Channel Blockers--chemical synthesis<br/>Sodium Channels--biosynthesis<br/>Succinates<br/>Synaptosomes--metabolism<br/>Tetrodotoxin--antagonists & inhibitors