TY  - GEN
AU  - Li,Tsai-Kun
AU  - Barbieri,Christopher M
AU  - Lin,Hsin-Chin
AU  - Rabson,Arnold B
AU  - Yang,Gengcheng
AU  - Fan,Yupeng
AU  - Gaffney,Barbara L
AU  - Jones,Roger A
AU  - Pilch,Daniel S
TI  - Drug targeting of HIV-1 RNA.DNA hybrid structures: thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replication
SN  - 0006-2960
PY  - 2004///0924
KW  - Aminoglycosides
KW  - pharmacology
KW  - Binding, Competitive
KW  - Circular Dichroism
KW  - DNA, Viral
KW  - antagonists & inhibitors
KW  - Drug Delivery Systems
KW  - methods
KW  - Enzyme Activation
KW  - genetics
KW  - HIV Reverse Transcriptase
KW  - HIV-1
KW  - drug effects
KW  - Humans
KW  - Hydrolysis
KW  - Neomycin
KW  - metabolism
KW  - Nucleic Acid Conformation
KW  - Nucleic Acid Heteroduplexes
KW  - Paromomycin
KW  - RNA, Viral
KW  - Reverse Transcriptase Inhibitors
KW  - Ribonuclease H
KW  - Ribostamycin
KW  - Thermodynamics
KW  - Virus Replication
N1  - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1021/bi0497345
ER  -