TY - GEN AU - Bianco,Roberto AU - Caputo,Roberta AU - Caputo,Rosa AU - Damiano,Vincenzo AU - De Placido,Sabino AU - Ficorella,Corrado AU - Agrawal,Sudhir AU - Bianco,A Raffaele AU - Ciardiello,Fortunato AU - Tortora,Giampaolo TI - Combined targeting of epidermal growth factor receptor and MDM2 by gefitinib and antisense MDM2 cooperatively inhibit hormone-independent prostate cancer SN - 1078-0432 PY - 2005///0119 KW - Animals KW - Antineoplastic Agents KW - pharmacology KW - Apoptosis KW - drug effects KW - Blotting, Western KW - Cell Line, Tumor KW - Cell Proliferation KW - Dose-Response Relationship, Drug KW - Drug Synergism KW - ErbB Receptors KW - metabolism KW - Fibroblast Growth Factor 2 KW - biosynthesis KW - Gefitinib KW - Humans KW - Male KW - Mice KW - Mice, Inbred BALB C KW - Mice, Nude KW - Mitogen-Activated Protein Kinases KW - Nuclear Proteins KW - genetics KW - Oligonucleotides, Antisense KW - Phosphorylation KW - Prostatic Neoplasms KW - Protein Biosynthesis KW - Protein Serine-Threonine Kinases KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins c-akt KW - Proto-Oncogene Proteins c-mdm2 KW - Quinazolines KW - Time Factors KW - Vascular Endothelial Growth Factor A KW - Xenograft Model Antitumor Assays N1 - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1158/1078-0432.CCR-03-0497 ER -