Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. [electronic resource]
- The Journal of biological chemistry Oct 2004
- 43136-47 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.M406406200 doi
Animals CCAAT-Enhancer-Binding Proteins CHO Cells--metabolism Cell Line Cell Nucleus--metabolism Cholesterol--metabolism Cricetinae DNA--chemistry DNA-Binding Proteins Diphosphonates--pharmacology Dose-Response Relationship, Drug Endoplasmic Reticulum--metabolism Fatty Acids--metabolism Fibroblasts--metabolism Humans Hydroxymethylglutaryl CoA Reductases--metabolism Immunoblotting Intracellular Signaling Peptides and Proteins Lipid Metabolism Membrane Proteins--genetics Models, Biological Mutagenesis, Site-Directed Mutation Peptides--chemistry Plasmids--metabolism RNA Interference Reverse Transcriptase Polymerase Chain Reaction Sterol Regulatory Element Binding Protein 1 Sterols--metabolism Subcellular Fractions Temperature Time Factors Transcription Factors Transfection Ubiquitin--metabolism