Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid. [electronic resource]
- Archives of biochemistry and biophysics Aug 2004
- 136-43 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0003-9861
10.1016/j.abb.2004.05.005 doi
Adenylyl Cyclases--metabolism Alanine--chemistry Aminobutyrates--pharmacology Animals Cells, Cultured Chromatography, High Pressure Liquid Cyclic AMP--metabolism Diabetes Mellitus--drug therapy Dipeptidyl Peptidase 4--chemistry Dose-Response Relationship, Drug Gastric Inhibitory Polypeptide--chemistry Glucagon--chemistry Glucagon-Like Peptide 1 Glucose--metabolism Humans Insulin--metabolism Insulin Secretion Islets of Langerhans--metabolism Mice Mice, Obese Models, Chemical Peptide Fragments--chemistry Peptides--chemistry Protein Precursors--chemistry Protein Structure, Tertiary Spectrometry, Mass, Electrospray Ionization Time Factors