TY  - GEN
AU  - Westra,Johanna
AU  - Doornbos-van der Meer,Berber
AU  - de Boer,Peter
AU  - van Leeuwen,Miek A
AU  - van Rijswijk,Martin H
AU  - Limburg,Pieter C
TI  - Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor
SN  - 1478-6362
PY  - 2005///0218
KW  - Cell Differentiation
KW  - drug effects
KW  - Cells, Cultured
KW  - Cyclooxygenase 2
KW  - Cytokines
KW  - biosynthesis
KW  - Gene Expression Regulation
KW  - Gene Expression Regulation, Enzymologic
KW  - Imidazoles
KW  - pharmacology
KW  - Interleukin-8
KW  - genetics
KW  - Intracellular Signaling Peptides and Proteins
KW  - Isoenzymes
KW  - MAP Kinase Signaling System
KW  - Macrophages
KW  - enzymology
KW  - Matrix Metalloproteinases
KW  - Mitogen-Activated Protein Kinases
KW  - Monocytes
KW  - Phosphorylation
KW  - Prostaglandin-Endoperoxide Synthases
KW  - Protein Serine-Threonine Kinases
KW  - metabolism
KW  - Pyridines
KW  - RNA, Messenger
KW  - Tumor Necrosis Factor-alpha
KW  - antagonists & inhibitors
KW  - p38 Mitogen-Activated Protein Kinases
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1186/ar1204
ER  -