Westra, Johanna <br/><br/>
Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor.  [electronic resource] 

 -  Arthritis research & therapy  2004 
 - R384-92 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1478-6362 
<br/><br/><label>Standard No.: </label>10.1186/ar1204  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Cell Differentiation--drug effects<br/>Cells, Cultured<br/>Cyclooxygenase 2<br/>Cytokines--biosynthesis<br/>Gene Expression Regulation--drug effects<br/>Gene Expression Regulation, Enzymologic--drug effects<br/>Imidazoles--pharmacology<br/>Interleukin-8--genetics<br/>Intracellular Signaling Peptides and Proteins<br/>Isoenzymes--genetics<br/>MAP Kinase Signaling System--drug effects<br/>Macrophages--enzymology<br/>Matrix Metalloproteinases--biosynthesis<br/>Mitogen-Activated Protein Kinases<br/>Monocytes--enzymology<br/>Phosphorylation--drug effects<br/>Prostaglandin-Endoperoxide Synthases--genetics<br/>Protein Serine-Threonine Kinases--metabolism<br/>Pyridines--pharmacology<br/>RNA, Messenger--biosynthesis<br/>Tumor Necrosis Factor-alpha--antagonists & inhibitors<br/>p38 Mitogen-Activated Protein Kinases--antagonists & inhibitors