Maedler, Kathrin <br/><br/>
Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.  [electronic resource] 

 -  Diabetes  Jul 2004 
 - 1706-13 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0012-1797 
<br/><br/><label>Standard No.: </label>10.2337/diabetes.53.7.1706  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>ATP-Binding Cassette Transporters<br/>Aged<br/>Apoptosis--drug effects<br/>Bridged Bicyclo Compounds, Heterocyclic--pharmacology<br/>Calcium--metabolism<br/>Calcium Channels, L-Type--metabolism<br/>Cells, Cultured<br/>Cyclic S-Oxides--pharmacology<br/>Diazoxide--pharmacology<br/>Drug Synergism<br/>Enzyme Activation--physiology<br/>Glucose--pharmacology<br/>Humans<br/>Interleukin-1--pharmacology<br/>Islets of Langerhans--drug effects<br/>Middle Aged<br/>Mitogen-Activated Protein Kinases--metabolism<br/>Potassium Channels--drug effects<br/>Potassium Channels, Inwardly Rectifying--drug effects<br/>Receptors, Drug<br/>Sulfonylurea Receptors<br/>Tolbutamide--pharmacology