Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt. [electronic resource]
- Oncogene Jul 2004
- 5781-91 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0950-9232
10.1038/sj.onc.1207698 doi
Apoptosis--drug effects Cells, Cultured Dose-Response Relationship, Drug G2 Phase--drug effects Microtubules--drug effects Mitosis--drug effects Mutation Nocodazole--pharmacology Paclitaxel--pharmacology Phosphorylation Protein Kinases--metabolism Protein Serine-Threonine Kinases--genetics Proto-Oncogene Proteins--genetics Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-bcl-2--drug effects Ribosomal Protein S6 Kinases, 70-kDa--metabolism Serine--metabolism Signal Transduction Sirolimus--pharmacology TOR Serine-Threonine Kinases