TY - GEN AU - Michalides,Rob AU - Griekspoor,Alexander AU - Balkenende,Astrid AU - Verwoerd,Desiree AU - Janssen,Lennert AU - Jalink,Kees AU - Floore,Arno AU - Velds,Arno AU - van't Veer,Laura AU - Neefjes,Jacques TI - Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer SN - 1535-6108 PY - 2004///0719 KW - Antineoplastic Agents, Hormonal KW - pharmacology KW - Binding Sites KW - Blotting, Western KW - Breast Neoplasms KW - enzymology KW - Cell Division KW - Cell Line, Tumor KW - Cyclic AMP-Dependent Protein Kinases KW - metabolism KW - Down-Regulation KW - Drug Resistance, Neoplasm KW - Enzyme Activation KW - Enzyme Inhibitors KW - Estradiol KW - analogs & derivatives KW - Estrogen Receptor Modulators KW - Estrogen Receptor alpha KW - Female KW - Fluorescence Resonance Energy Transfer KW - Fulvestrant KW - Humans KW - Luciferases KW - Microscopy, Confocal KW - Models, Biological KW - Nucleic Acid Hybridization KW - Oligonucleotide Array Sequence Analysis KW - Phosphorylation KW - Protein Conformation KW - Protein Structure, Tertiary KW - RNA Interference KW - Receptors, Estrogen KW - chemistry KW - Serine KW - Tamoxifen KW - Time Factors KW - Transcriptional Activation KW - Transfection N1 - Publication Type: Journal Article UR - https://doi.org/10.1016/j.ccr.2004.05.016 ER -