TY  - GEN
AU  - Ghadessy,Farid J
AU  - Ramsay,Nicola
AU  - Boudsocq,François
AU  - Loakes,David
AU  - Brown,Anthony
AU  - Iwai,Shigenori
AU  - Vaisman,Alexandra
AU  - Woodgate,Roger
AU  - Holliger,Philipp
TI  - Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution
SN  - 1087-0156
PY  - 2005///0321
KW  - Base Pair Mismatch
KW  - genetics
KW  - Biotin
KW  - chemistry
KW  - DNA
KW  - DNA Mutational Analysis
KW  - DNA Probes
KW  - chemical synthesis
KW  - Deoxyadenine Nucleotides
KW  - Deoxyguanine Nucleotides
KW  - Deoxyribose
KW  - Deoxyuracil Nucleotides
KW  - Directed Molecular Evolution
KW  - methods
KW  - Fluorescein-5-isothiocyanate
KW  - Indoles
KW  - Kinetics
KW  - Microarray Analysis
KW  - Models, Molecular
KW  - Mutation
KW  - Point Mutation
KW  - Polymerase Chain Reaction
KW  - Pyrimidine Dimers
KW  - Rhodamines
KW  - Sequence Analysis, DNA
KW  - Substrate Specificity
KW  - Taq Polymerase
KW  - Thionucleotides
N1  - Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1038/nbt974
ER  -