TY  - GEN
AU  - Smith-Jones,Peter M
AU  - Solit,David B
AU  - Akhurst,Timothy
AU  - Afroze,Farzana
AU  - Rosen,Neal
AU  - Larson,Steven M
TI  - Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors
SN  - 1087-0156
PY  - 2005///0321
KW  - Animals
KW  - Antibodies, Monoclonal
KW  - chemistry
KW  - Antibodies, Monoclonal, Humanized
KW  - Antineoplastic Agents
KW  - Benzoquinones
KW  - Blotting, Western
KW  - Cell Line, Tumor
KW  - Copper Radioisotopes
KW  - Female
KW  - HSP90 Heat-Shock Proteins
KW  - antagonists & inhibitors
KW  - Heterocyclic Compounds, 1-Ring
KW  - Humans
KW  - Immunoblotting
KW  - Immunoglobulin Fab Fragments
KW  - Indium Radioisotopes
KW  - Isotope Labeling
KW  - Lactams, Macrocyclic
KW  - Mice
KW  - Mice, Nude
KW  - Molecular Probe Techniques
KW  - Neoplasms
KW  - Phosphatidylinositol 3-Kinases
KW  - metabolism
KW  - Positron-Emission Tomography
KW  - methods
KW  - Protein Serine-Threonine Kinases
KW  - Receptor, ErbB-2
KW  - drug effects
KW  - Rifabutin
KW  - analogs & derivatives
KW  - Tissue Distribution
KW  - Trastuzumab
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1038/nbt968
ER  -