Hoivik, Debie J

Fibrates induce hepatic peroxisome and mitochondrial proliferation without overt evidence of cellular proliferation and oxidative stress in cynomolgus monkeys. [electronic resource] - Carcinogenesis Sep 2004 - 1757-69 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0143-3334

10.1093/carcin/bgh182 doi


Acyl-CoA Oxidase--metabolism
Animals
Apoptosis
Area Under Curve
Catalase--genetics
Cell Division--drug effects
Clofibric Acid--analogs & derivatives
Cyclin D1--metabolism
Cyclin-Dependent Kinase Inhibitor p21
Cyclins--metabolism
Endoplasmic Reticulum, Smooth--drug effects
Fenofibrate--toxicity
Fibric Acids
Gene Expression Profiling
Glutathione Peroxidase--genetics
Liver--cytology
Macaca fascicularis
Male
Mitochondria--drug effects
Mitotic Index
Organ Size--drug effects
Oxidative Stress--drug effects
Peroxisomes--drug effects
Proliferating Cell Nuclear Antigen--metabolism
RNA, Messenger--metabolism
Receptors, Cytoplasmic and Nuclear--metabolism
Thioredoxin-Disulfide Reductase--metabolism
Transcription Factors--metabolism