Chronic morphine-induced loss of the facilitative interaction between vasoactive intestinal polypeptide and delta-opioid: involvement of protein kinase C and phospholipase Cbetas. [electronic resource]
- Brain research Jun 2004
- 1-9 p. digital
Publication Type: Journal Article
0006-8993
10.1016/j.brainres.2004.02.026 doi
Analgesics, Opioid--pharmacology Animals Calcium Signaling--drug effects Central Nervous System--drug effects Cyclic AMP--biosynthesis Down-Regulation--drug effects Drug Administration Schedule Drug Tolerance--physiology Enkephalin, D-Penicillamine (2,5)---pharmacology Female Isoenzymes--metabolism Morphine--pharmacology Nociceptors--drug effects Pain--drug therapy Phosphatidylinositols--metabolism Phospholipase C beta Phosphorylation--drug effects Protein Isoforms--drug effects Protein Kinase C--drug effects Rats Rats, Sprague-Dawley Receptors, Opioid, delta--metabolism Spinal Cord--drug effects Type C Phospholipases--metabolism Vasoactive Intestinal Peptide--metabolism Visceral Afferents--drug effects