Vignati, Luisella A <br/><br/>
A human and mouse pregnane X receptor reporter gene assay in combination with cytotoxicity measurements as a tool to evaluate species-specific CYP3A induction.  [electronic resource] 

 -  Toxicology  Jun 2004 
 - 23-33 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article 
<br/><br/><label>ISSN: </label>0300-483X 
<br/><br/><label>Standard No.: </label>10.1016/j.tox.2003.12.018  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Androstadienes--toxicity<br/>Animals<br/>Antineoplastic Agents--toxicity<br/>Biological Assay<br/>Cell Line, Tumor<br/>Cell Survival--drug effects<br/>Cytochrome P-450 CYP3A<br/>Cytochrome P-450 Enzyme System--biosynthesis<br/>Dose-Response Relationship, Drug<br/>Enzyme Induction<br/>Formazans--metabolism<br/>Genes, Reporter<br/>Hepatocytes--drug effects<br/>Humans<br/>L-Lactate Dehydrogenase--metabolism<br/>Mice<br/>Pregnane X Receptor<br/>Receptors, Cytoplasmic and Nuclear--genetics<br/>Receptors, Steroid--genetics<br/>Species Specificity<br/>Tetrazolium Salts--metabolism<br/>Xenobiotics--toxicity