Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis. [electronic resource]
- Cell death and differentiation Aug 2004
- 915-23 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
1350-9047
10.1038/sj.cdd.4401416 doi
Animals Apoptosis--drug effects Apoptosis Regulatory Proteins BH3 Interacting Domain Death Agonist Protein CASP8 and FADD-Like Apoptosis Regulating Protein Carrier Proteins--metabolism Caspase 9 Caspases--metabolism Genes, bcl-2--physiology Humans Inhibitor of Apoptosis Proteins Intracellular Signaling Peptides and Proteins--metabolism Melanoma--metabolism Membrane Glycoproteins--metabolism Microtubule-Associated Proteins--metabolism Neoplasm Proteins Proteins--metabolism RNA, Small Interfering--genetics Survivin TNF-Related Apoptosis-Inducing Ligand Tumor Cells, Cultured Tumor Necrosis Factor-alpha--pharmacology X-Linked Inhibitor of Apoptosis Protein