TY  - GEN
AU  - Claveau,D
AU  - Chen,S L
AU  - O'Keefe,S
AU  - Zaller,D M
AU  - Styhler,A
AU  - Liu,S
AU  - Huang,Z
AU  - Nicholson,D W
AU  - Mancini,J A
TI  - Preferential inhibition of T helper 1, but not T helper 2, cytokines in vitro by L-826,141 [4-[2-(3,4-Bisdifluromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]3-methylpyridine-1-oxide], a potent and selective phosphodiesterase 4 inhibitor
SN  - 0022-3565
PY  - 2005///0328
KW  - 3',5'-Cyclic-AMP Phosphodiesterases
KW  - antagonists & inhibitors
KW  - Animals
KW  - Cyclic Nucleotide Phosphodiesterases, Type 4
KW  - Cytokines
KW  - Dose-Response Relationship, Drug
KW  - Humans
KW  - Immunosuppressive Agents
KW  - pharmacology
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Mice, Transgenic
KW  - Phosphodiesterase Inhibitors
KW  - chemistry
KW  - Pyridines
KW  - Th1 Cells
KW  - drug effects
KW  - Th2 Cells
N1  - Publication Type: Comparative Study; Journal Article
UR  - https://doi.org/10.1124/jpet.103.064691
ER  -