Claveau, D <br/><br/>
Preferential inhibition of T helper 1, but not T helper 2, cytokines in vitro by L-826,141 [4-[2-(3,4-Bisdifluromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]3-methylpyridine-1-oxide], a potent and selective phosphodiesterase 4 inhibitor.  [electronic resource] 

 -  The Journal of pharmacology and experimental therapeutics  Aug 2004 
 - 752-60 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article 
<br/><br/><label>ISSN: </label>0022-3565 
<br/><br/><label>Standard No.: </label>10.1124/jpet.103.064691  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>3',5'-Cyclic-AMP Phosphodiesterases--antagonists & inhibitors<br/>Animals<br/>Cyclic Nucleotide Phosphodiesterases, Type 4<br/>Cytokines--antagonists & inhibitors<br/>Dose-Response Relationship, Drug<br/>Humans<br/>Immunosuppressive Agents--pharmacology<br/>Mice<br/>Mice, Inbred BALB C<br/>Mice, Transgenic<br/>Phosphodiesterase Inhibitors--chemistry<br/>Pyridines--chemistry<br/>Th1 Cells--drug effects<br/>Th2 Cells--drug effects