Li, Pengfei

p27(Kip1) stabilization and G(1) arrest by 1,25-dihydroxyvitamin D(3) in ovarian cancer cells mediated through down-regulation of cyclin E/cyclin-dependent kinase 2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase. [electronic resource] - The Journal of biological chemistry Jun 2004 - 25260-7 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

0021-9258

10.1074/jbc.M311052200 doi


CDC2-CDC28 Kinases--genetics
Calcitriol--pharmacology
Cell Cycle Proteins--physiology
Cell Division--drug effects
Cell Line, Tumor
Cyclin E--genetics
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Cyclins--physiology
Down-Regulation
Female
G1 Phase--drug effects
Gene Expression Regulation, Neoplastic
Humans
Mitosis
Ovarian Neoplasms--pathology
Phosphorylation
S-Phase Kinase-Associated Proteins--physiology
SKP Cullin F-Box Protein Ligases--physiology
Tumor Suppressor Proteins--physiology