Synthesis, antimalarial activity, and molecular modeling of new pyrrolo[1,2-a]quinoxalines, bispyrrolo[1,2-a]quinoxalines, bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and bispyrrolo[1,2-a]thieno[3,2-e]pyrazines. [electronic resource]
- Journal of medicinal chemistry Apr 2004
- 1997-2009 p. digital
Publication Type: Journal Article
0022-2623
10.1021/jm0310840 doi
Animals Antimalarials--chemical synthesis Cell Line Crystallography, X-Ray Drug Resistance Erythrocytes--parasitology Hemeproteins--chemistry Humans In Vitro Techniques Models, Molecular Plasmodium falciparum--drug effects Protein Binding Pyrazines--chemical synthesis Pyridines--chemical synthesis Pyrroles--chemical synthesis Quinoxalines--chemical synthesis Rats Structure-Activity Relationship