TY  - GEN
AU  - Laudon,Hanna
AU  - Karlström,Helena
AU  - Mathews,Paul M
AU  - Farmery,Mark R
AU  - Gandy,Samuel E
AU  - Lundkvist,Johan
AU  - Lendahl,Urban
AU  - Näslund,Jan
TI  - Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis
SN  - 0021-9258
PY  - 2004///0708
KW  - Alanine
KW  - chemistry
KW  - Amino Acid Sequence
KW  - Amyloid Precursor Protein Secretases
KW  - Animals
KW  - Aspartic Acid Endopeptidases
KW  - Cells, Cultured
KW  - Embryo, Mammalian
KW  - cytology
KW  - Endopeptidases
KW  - metabolism
KW  - Enzyme-Linked Immunosorbent Assay
KW  - Genes, Reporter
KW  - Immunoblotting
KW  - Luciferases
KW  - Membrane Proteins
KW  - Mice
KW  - Molecular Sequence Data
KW  - Mutagenesis, Site-Directed
KW  - Mutation
KW  - Precipitin Tests
KW  - Presenilin-1
KW  - Protein Structure, Tertiary
KW  - Stem Cells
KW  - Subcellular Fractions
KW  - Transfection
KW  - Tyrosine
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1074/jbc.M401277200
ER  -