TY  - GEN
AU  - Wityak,John
AU  - Hobbs,Frank W
AU  - Gardner,Daniel S
AU  - Santella,Joseph B
AU  - Petraitis,Joseph J
AU  - Sun,Jung-Hui
AU  - Favata,Margaret F
AU  - Daulerio,Andrea J
AU  - Horiuchi,Kurumi Y
AU  - Copeland,Robert A
AU  - Scherle,Peggy A
AU  - Jaffe,Bruce D
AU  - Trzaskos,James M
AU  - Magolda,Ronald L
AU  - Trainor,George L
AU  - Duncia,John V
TI  - Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors
SN  - 0960-894X
PY  - 2004///1028
KW  - Animals
KW  - Butadienes
KW  - chemical synthesis
KW  - COS Cells
KW  - Chemistry, Pharmaceutical
KW  - methods
KW  - Chlorocebus aethiops
KW  - Enzyme Inhibitors
KW  - Mitogen-Activated Protein Kinase Kinases
KW  - antagonists & inhibitors
KW  - Nitriles
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.bmcl.2004.01.012
ER  -