Zhang, Donglei

Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals. [electronic resource] - The Journal of biological chemistry May 2004 - 19683-90 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M313145200 doi


Androstadienes--pharmacology
Animals
Blotting, Western
Carcinoma, Lewis Lung--metabolism
Cell Line, Tumor
Chloramphenicol O-Acetyltransferase--metabolism
Chromones--pharmacology
Enzyme Activation
Enzyme Inhibitors--pharmacology
Extracellular Matrix--metabolism
Flavonoids--pharmacology
Gene Expression Regulation, Enzymologic
Genes, Dominant
Genes, Reporter
Insulin-Like Growth Factor I--metabolism
Matrix Metalloproteinase 2--biosynthesis
Mice
Mitogen-Activated Protein Kinases--metabolism
Models, Biological
Morpholines--pharmacology
PTEN Phosphohydrolase
Phosphatidylinositol 3-Kinases--metabolism
Phosphoric Monoester Hydrolases--metabolism
Plasmids--metabolism
Proto-Oncogene Proteins c-raf--metabolism
RNA, Messenger--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
Sirolimus--metabolism
Time Factors
Tumor Suppressor Proteins--metabolism
Wortmannin