TY - GEN AU - Velders,Aldrik H AU - Bergamo,Alberta AU - Alessio,Enzo AU - Zangrando,Ennio AU - Haasnoot,Jaap G AU - Casarsa,Claudia AU - Cocchietto,Moreno AU - Zorzet,Sonia AU - Sava,Gianni TI - Synthesis and chemical-pharmacological characterization of the antimetastatic NAMI-A-type Ru(III) complexes (Hdmtp)[trans-RuCl4(dmso-S)(dmtp)], (Na)[trans-RuCl4(dmso-S)(dmtp)], and [mer-RuCl3(H2O)(dmso-S)(dmtp)] (dmtp = 5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine) SN - 0022-2623 PY - 2004///0413 KW - Animals KW - Antineoplastic Agents KW - chemical synthesis KW - Cell Cycle KW - drug effects KW - Cell Line, Tumor KW - Cell Survival KW - Crystallography, X-Ray KW - Drug Screening Assays, Antitumor KW - Hydrolysis KW - Kidney KW - Liver KW - Lung Neoplasms KW - drug therapy KW - Magnetic Resonance Spectroscopy KW - Mammary Neoplasms, Animal KW - pathology KW - Matrix Metalloproteinase 9 KW - chemistry KW - Mice KW - Molecular Structure KW - Neoplasm Invasiveness KW - Neoplasm Metastasis KW - prevention & control KW - Organometallic Compounds KW - Ruthenium KW - pharmacokinetics KW - Spectrophotometry, Ultraviolet KW - Structure-Activity Relationship KW - Tissue Distribution N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1021/jm030984d ER -