Copper induces increased beta-sheet content in the scrapie-susceptible ovine prion protein PrPVRQ compared with the resistant allelic variant PrPARR. [electronic resource]
- The Biochemical journal May 2004
- 273-82 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1470-8728
10.1042/BJ20031767 doi
Alleles Amino Acid Sequence Animals Antibodies, Monoclonal--immunology Circular Dichroism Copper--pharmacology Drug Resistance Endopeptidase K--pharmacology Genetic Predisposition to Disease Immunity, Innate Manganese--pharmacology Mice Mice, Knockout Nickel--pharmacology Peptide Fragments--immunology Polymorphism, Genetic PrPC Proteins--chemistry Protein Denaturation Protein Folding Protein Structure, Secondary--drug effects Recombinant Fusion Proteins--chemistry Scrapie--genetics Sheep--genetics Sheep Diseases--genetics Temperature