Tanaka, Yoshiko <br/><br/>
Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis.  [electronic resource] 

 -  International journal of cancer  Apr 2004 
 - 336-47 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0020-7136 
<br/><br/><label>Standard No.: </label>10.1002/ijc.11700  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Cell Division--drug effects<br/>Down-Regulation--drug effects<br/>Enzyme Activation<br/>Female<br/>Humans<br/>Insulin-Like Growth Factor Binding Protein 4--metabolism<br/>Insulin-Like Growth Factor I--pharmacology<br/>MAP Kinase Signaling System<br/>Membrane Glycoproteins--pharmacology<br/>Mitogen-Activated Protein Kinase 1--metabolism<br/>Mitogen-Activated Protein Kinase 3<br/>Mitogen-Activated Protein Kinases--metabolism<br/>Neoplasm Invasiveness<br/>Neoplasm Metastasis<br/>Oligonucleotides, Antisense--pharmacology<br/>Ovarian Neoplasms--metabolism<br/>Pregnancy-Associated Plasma Protein-A--genetics<br/>Protein Serine-Threonine Kinases<br/>Proto-Oncogene Proteins--metabolism<br/>Proto-Oncogene Proteins c-akt<br/>RNA, Messenger--metabolism<br/>Serine Proteinase Inhibitors--pharmacology<br/>Trypsin Inhibitor, Kunitz Soybean--pharmacology<br/>Tumor Cells, Cultured<br/>Urokinase-Type Plasminogen Activator--genetics