TY  - GEN
AU  - Taylor,E C
AU  - Kuhnt,D
AU  - Shih,C
AU  - Rinzel,S M
AU  - Grindey,G B
AU  - Barredo,J
AU  - Jannatipour,M
AU  - Moran,R G
TI  - A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase
SN  - 0022-2623
PY  - 1992///1228
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemical synthesis
KW  - Glutamates
KW  - Guanine
KW  - analogs & derivatives
KW  - Humans
KW  - Leukemia L1210
KW  - drug therapy
KW  - Leukemia, Lymphoid
KW  - Mice
KW  - Pemetrexed
KW  - Structure-Activity Relationship
KW  - Thymidylate Synthase
KW  - antagonists & inhibitors
KW  - Tumor Cells, Cultured
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1021/jm00101a023
ER  -