Taylor, E C <br/><br/>
A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase.  [electronic resource] 

 -  Journal of medicinal chemistry  Nov 1992 
 - 4450-4 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm00101a023  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--chemical synthesis<br/>Glutamates--chemical synthesis<br/>Guanine--analogs & derivatives<br/>Humans<br/>Leukemia L1210--drug therapy<br/>Leukemia, Lymphoid--drug therapy<br/>Mice<br/>Pemetrexed<br/>Structure-Activity Relationship<br/>Thymidylate Synthase--antagonists & inhibitors<br/>Tumor Cells, Cultured