TY  - GEN
AU  - Koyano,Satoru
AU  - Kurose,Kouichi
AU  - Saito,Yoshiro
AU  - Ozawa,Shogo
AU  - Hasegawa,Ryuichi
AU  - Komamura,Kazuo
AU  - Ueno,Kazuyuki
AU  - Kamakura,Shiro
AU  - Kitakaze,Masafumi
AU  - Nakajima,Toshiharu
AU  - Matsumoto,Kenji
AU  - Akasawa,Akira
AU  - Saito,Hirohisa
AU  - Sawada,Jun-Ichi
TI  - Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region
SN  - 0090-9556
PY  - 2004///0913
KW  - Amino Acid Sequence
KW  - Animals
KW  - Biotransformation
KW  - drug effects
KW  - Blotting, Western
KW  - COS Cells
KW  - Cell Line, Tumor
KW  - Chlorocebus aethiops
KW  - Clotrimazole
KW  - pharmacology
KW  - Cytochrome P-450 CYP3A
KW  - Cytochrome P-450 Enzyme System
KW  - genetics
KW  - DNA
KW  - Electrophoretic Mobility Shift Assay
KW  - Enhancer Elements, Genetic
KW  - Exons
KW  - Genes, Reporter
KW  - Humans
KW  - Immunohistochemistry
KW  - Luciferases
KW  - Molecular Sequence Data
KW  - Paclitaxel
KW  - Plasmids
KW  - Pregnane X Receptor
KW  - Promoter Regions, Genetic
KW  - Receptors, Cytoplasmic and Nuclear
KW  - Receptors, Steroid
KW  - Rifampin
KW  - Transcriptional Activation
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1124/dmd.32.1.149
ER  -