Koyano, Satoru <br/><br/>
Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  Jan 2004 
 - 149-54 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0090-9556 
<br/><br/><label>Standard No.: </label>10.1124/dmd.32.1.149  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Sequence<br/>Animals<br/>Biotransformation--drug effects<br/>Blotting, Western<br/>COS Cells<br/>Cell Line, Tumor<br/>Chlorocebus aethiops<br/>Clotrimazole--pharmacology<br/>Cytochrome P-450 CYP3A<br/>Cytochrome P-450 Enzyme System--genetics<br/>DNA--genetics<br/>Electrophoretic Mobility Shift Assay<br/>Enhancer Elements, Genetic--genetics<br/>Exons--genetics<br/>Genes, Reporter--genetics<br/>Humans<br/>Immunohistochemistry<br/>Luciferases--genetics<br/>Molecular Sequence Data<br/>Paclitaxel--pharmacology<br/>Plasmids--genetics<br/>Pregnane X Receptor<br/>Promoter Regions, Genetic--genetics<br/>Receptors, Cytoplasmic and Nuclear--genetics<br/>Receptors, Steroid--genetics<br/>Rifampin--pharmacology<br/>Transcriptional Activation--genetics