G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells. [electronic resource]
- Circulation Jan 2004
- 399-405 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1524-4539
10.1161/01.CIR.0000109498.77895.6F doi
Cells, Cultured Endothelium, Vascular--cytology Gene Expression Regulation, Enzymologic Humans Insulin--pharmacology Insulin Receptor Substrate Proteins Mitogen-Activated Protein Kinases--metabolism Nitric Oxide Synthase--genetics Nitric Oxide Synthase Type III Phosphatidylinositol 3-Kinases--metabolism Phosphoproteins--genetics Phosphorylation--drug effects Polymorphism, Genetic Protein Serine-Threonine Kinases Proto-Oncogene Proteins--metabolism Proto-Oncogene Proteins c-akt RNA, Messenger--metabolism Signal Transduction