Chen, D <br/><br/>
Peptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach.  [electronic resource] 

 -  Antimicrobial agents and chemotherapy  Jan 2004 
 - 250-61 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0066-4804 
<br/><br/><label>Standard No.: </label>10.1128/AAC.48.1.250-261.2004  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Algorithms<br/>Amidohydrolases--antagonists & inhibitors<br/>Animals<br/>Anti-Infective Agents--chemical synthesis<br/>Antineoplastic Agents--chemical synthesis<br/>Binding Sites<br/>Cell Line, Tumor<br/>Chelating Agents--chemistry<br/>Combinatorial Chemistry Techniques<br/>Drug Design<br/>Drug Screening Assays, Antitumor<br/>Enzyme Inhibitors--chemical synthesis<br/>Escherichia coli--drug effects<br/>Female<br/>Half-Life<br/>Humans<br/>Hydroxamic Acids--chemical synthesis<br/>Lethal Dose 50<br/>Mice<br/>Models, Molecular<br/>Peptide Library<br/>Proline--analogs & derivatives<br/>Sepsis--drug therapy<br/>Structure-Activity Relationship<br/>Tissue Distribution<br/>X-Ray Diffraction