The 2G single nucleotide polymorphism (SNP) in the MMP-1 promoter contributes to high levels of MMP-1 transcription in MCF-7/ADR breast cancer cells. [electronic resource]
- Breast cancer research and treatment Nov 2003
- 75-82 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
0167-6806
10.1023/B:BREA.0000003948.14026.7c doi
Binding Sites--genetics Breast Neoplasms--genetics Cell Line, Tumor--drug effects Collagen Type I--metabolism Down-Regulation Enzyme Inhibitors--pharmacology Flavonoids--pharmacology Gene Expression Regulation, Enzymologic--drug effects Humans Imidazoles--pharmacology In Vitro Techniques Matrix Metalloproteinase 1--genetics Mitogen-Activated Protein Kinase 1--antagonists & inhibitors Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases--antagonists & inhibitors Polymorphism, Single Nucleotide Promoter Regions, Genetic--genetics Pyridines--pharmacology RNA, Messenger--genetics Transcription Factor AP-1--metabolism Transcription, Genetic Transfection