Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions. [electronic resource]
- The Journal of biological chemistry Mar 2004
- 10710-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.M308434200 doi
1-Methyl-4-phenylpyridinium--pharmacology Acetylcysteine--analogs & derivatives Animals Brain--metabolism Caspase 3 Caspase Inhibitors Caspases--metabolism Cysteine Endopeptidases--metabolism Dopamine--metabolism Dopamine Agents--metabolism Dose-Response Relationship, Drug Enzyme Inhibitors--pharmacology Herbicides--pharmacology Immunoblotting Immunohistochemistry Ions L-Lactate Dehydrogenase--metabolism Leupeptins--pharmacology MAP Kinase Signaling System Male Mitochondria--metabolism Mitogen-Activated Protein Kinase 1--metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases--metabolism Multienzyme Complexes--antagonists & inhibitors Nerve Tissue Proteins--metabolism Neurons--metabolism Phosphorylation Proteasome Endopeptidase Complex Rats Rats, Wistar Rotenone--metabolism Synucleins Time Factors Ubiquitin--metabolism alpha-Synuclein