TY  - GEN
AU  - Kase,Hiroshi
AU  - Aoyama,S
AU  - Ichimura,M
AU  - Ikeda,K
AU  - Ishii,A
AU  - Kanda,T
AU  - Koga,K
AU  - Koike,N
AU  - Kurokawa,M
AU  - Kuwana,Y
AU  - Mori,A
AU  - Nakamura,J
AU  - Nonaka,H
AU  - Ochi,M
AU  - Saki,M
AU  - Shimada,J
AU  - Shindou,T
AU  - Shiozaki,S
AU  - Suzuki,F
AU  - Takeda,M
AU  - Yanagawa,K
AU  - Richardson,P J
AU  - Jenner,P
AU  - Bedard,P
AU  - Borrelli,E
AU  - Hauser,R A
AU  - Chase,T N
TI  - Progress in pursuit of therapeutic A2A antagonists: the adenosine A2A receptor selective antagonist KW6002: research and development toward a novel nondopaminergic therapy for Parkinson's disease
SN  - 1526-632X
PY  - 2004///0211
KW  - Adenosine A2 Receptor Antagonists
KW  - Animals
KW  - Antiparkinson Agents
KW  - adverse effects
KW  - Clinical Trials as Topic
KW  - statistics & numerical data
KW  - Corpus Striatum
KW  - cytology
KW  - Disease Models, Animal
KW  - Drug Evaluation, Preclinical
KW  - Dyskinesia, Drug-Induced
KW  - prevention & control
KW  - Globus Pallidus
KW  - Humans
KW  - Levodopa
KW  - Mice
KW  - Mice, Knockout
KW  - Motor Activity
KW  - drug effects
KW  - Neurons
KW  - Oxidopamine
KW  - Parkinson Disease
KW  - drug therapy
KW  - Parkinsonian Disorders
KW  - chemically induced
KW  - Primates
KW  - Purines
KW  - therapeutic use
KW  - Rats
KW  - Receptor, Adenosine A2A
KW  - metabolism
KW  - Receptors, Dopamine D2
KW  - deficiency
KW  - gamma-Aminobutyric Acid
N1  - Publication Type: Journal Article; Review
UR  - https://doi.org/10.1212/01.wnl.0000095219.22086.31
ER  -