Hagglund, Ryan

Herpes simplex virus 1 mutant in which the ICP0 HUL-1 E3 ubiquitin ligase site is disrupted stabilizes cdc34 but degrades D-type cyclins and exhibits diminished neurotoxicity. [electronic resource] - Journal of virology Dec 2003 - 13194-202 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0022-538X

10.1128/jvi.77.24.13194-13202.2003 doi


Anaphase-Promoting Complex-Cyclosome
Animals
Brain Diseases--virology
Cell Line
Cyclin D1--metabolism
Cyclin D3
Cyclins--metabolism
Gene Deletion
Herpes Simplex--virology
Herpesvirus 1, Human--genetics
Humans
Immediate-Early Proteins--genetics
Mice
Mice, Inbred CBA
Mutation
Ubiquitin-Conjugating Enzymes
Ubiquitin-Protein Ligase Complexes--metabolism
Ubiquitin-Protein Ligases--genetics
Virulence