Hook, Vivian Y H

Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway. [electronic resource] - Journal of neuroscience research Nov 2003 - 393-405 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0360-4012

10.1002/jnr.10784 doi


Alzheimer Disease--genetics
Amyloid Precursor Protein Secretases
Amyloid beta-Peptides--metabolism
Animals
Aspartic Acid Endopeptidases--metabolism
Cells, Cultured
Chromaffin Cells--drug effects
Cysteine Endopeptidases--metabolism
Cysteine Proteinase Inhibitors--pharmacology
Dithiothreitol--pharmacology
Endopeptidases--metabolism
Extracellular Space--metabolism
Glutathione--pharmacology
Leucine--analogs & derivatives
Mice
Mice, Knockout
Mutation
Neurons--drug effects
Nicotine--pharmacology
Nicotinic Agonists--pharmacology
Peptide Fragments--metabolism
Potassium Chloride--pharmacology
Secretory Vesicles--metabolism
Substrate Specificity
Time Factors