TY - GEN AU - Debnath,Jayanta AU - Walker,Stephanie J AU - Brugge,Joan S TI - Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner SN - 0021-9525 PY - 2003///1203 KW - Antibiotics, Antineoplastic KW - pharmacology KW - Apoptosis KW - Breast KW - cytology KW - Cell Division KW - drug effects KW - Cell Line KW - Cell Line, Transformed KW - Cell Polarity KW - Cell Size KW - Cell Survival KW - Cyclin D1 KW - metabolism KW - DNA KW - analysis KW - Dose-Response Relationship, Drug KW - Enzyme Activation KW - Epithelial Cells KW - Humans KW - Morphogenesis KW - Protein Kinase Inhibitors KW - Protein Kinases KW - Protein Serine-Threonine Kinases KW - Proto-Oncogene Proteins KW - genetics KW - Proto-Oncogene Proteins c-akt KW - Retroviridae KW - Sirolimus KW - TOR Serine-Threonine Kinases N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1083/jcb.200304159 ER -