Repression of mitogen-activated protein kinase (MAPK) phosphatase-1 by anthracyclines contributes to their antiapoptotic activation of p44/42-MAPK. [electronic resource]
- The Journal of pharmacology and experimental therapeutics Dec 2003
- 861-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0022-3565
10.1124/jpet.103.055806 doi
Animals Anthracyclines--pharmacology Apoptosis--drug effects Blotting, Western Breast Neoplasms--enzymology Cell Line, Tumor Clone Cells Dual Specificity Phosphatase 1 Enzyme Activation--drug effects Enzyme Inhibitors--pharmacology Epithelial Cells--drug effects Female Fluorescent Antibody Technique Gene Silencing--drug effects Humans Luciferases--biosynthesis Mice Mice, Knockout Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases--metabolism Phosphorylation Promoter Regions, Genetic--drug effects Protein Phosphatase 1 Protein Tyrosine Phosphatases--antagonists & inhibitors RNA, Messenger--biosynthesis Reverse Transcriptase Polymerase Chain Reaction Signal Transduction--drug effects Transcription, Genetic