Senior, Suzanne J

Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme. [electronic resource] - Bioorganic & medicinal chemistry letters Nov 2003 - 3685-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0960-894X

10.1016/j.bmcl.2003.08.015 doi


3-Oxoacyl-(Acyl-Carrier-Protein) Synthase--antagonists & inhibitors
Acetyltransferases--antagonists & inhibitors
Alkylation
Anti-Bacterial Agents--pharmacology
Fatty Acid Synthase, Type II
Fatty Acid Synthases--antagonists & inhibitors
Multienzyme Complexes--antagonists & inhibitors
Mycobacterium tuberculosis--drug effects
Mycolic Acids--metabolism
Recombinant Proteins--metabolism
Thiophenes--pharmacology