TY - GEN AU - Bellido,Teresita AU - Ali,A Afshan AU - Plotkin,Lilian I AU - Fu,Qiang AU - Gubrij,Igor AU - Roberson,Paula K AU - Weinstein,Robert S AU - O'Brien,Charles A AU - Manolagas,Stavros C AU - Jilka,Robert L TI - Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism SN - 0021-9258 PY - 2004///0115 KW - Animals KW - Apoptosis KW - Blotting, Western KW - Bone Resorption KW - Calcium KW - metabolism KW - Carrier Proteins KW - Cells, Cultured KW - Core Binding Factor Alpha 1 Subunit KW - Culture Media, Conditioned KW - pharmacology KW - Cyclic AMP Response Element-Binding Protein KW - Cyclic AMP-Dependent Protein Kinases KW - Cysteine Endopeptidases KW - Dactinomycin KW - Female KW - HeLa Cells KW - Humans KW - Kinetics KW - Membrane Glycoproteins KW - Mice KW - Mice, Inbred C57BL KW - Models, Biological KW - Models, Genetic KW - Multienzyme Complexes KW - Neoplasm Proteins KW - Osteoblasts KW - Parathyroid Hormone KW - Phosphorylation KW - Proteasome Endopeptidase Complex KW - Proto-Oncogene Proteins c-bcl-2 KW - RANK Ligand KW - RNA KW - RNA, Messenger KW - Receptor Activator of Nuclear Factor-kappa B KW - Signal Transduction KW - Time Factors KW - Transcription Factors KW - Transcription, Genetic KW - bcl-Associated Death Protein N1 - Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1074/jbc.M307444200 ER -