TY - GEN AU - Park,Moon-Taek AU - Choi,Jung-A AU - Kim,Min-Jeong AU - Um,Hong-Duck AU - Bae,Sangwoo AU - Kang,Chang-Mo AU - Cho,Chul-Koo AU - Kang,Seongman AU - Chung,Hee Yong AU - Lee,Yun-Sil AU - Lee,Su-Jae TI - Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells SN - 0021-9258 PY - 2004///0115 KW - Apoptosis KW - Blotting, Western KW - Caspase 8 KW - Caspase 9 KW - Caspases KW - metabolism KW - Cell Death KW - Cell Line KW - Cell Line, Tumor KW - Cytochromes c KW - Cytosol KW - Down-Regulation KW - Enzyme Activation KW - Enzyme Inhibitors KW - pharmacology KW - Flow Cytometry KW - Humans KW - Jurkat Cells KW - Membrane Potentials KW - Microscopy, Fluorescence KW - Mitochondria KW - Mitogen-Activated Protein Kinase 1 KW - Mitogen-Activated Protein Kinase 3 KW - Mitogen-Activated Protein Kinases KW - Models, Biological KW - Phosphorylation KW - Plasmids KW - Protein Transport KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins c-bcl-2 KW - Sphingosine KW - analogs & derivatives KW - Tetradecanoylphorbol Acetate KW - Time Factors KW - bcl-2-Associated X Protein KW - p38 Mitogen-Activated Protein Kinases N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1074/jbc.M309011200 ER -