Park, Moon-Taek <br/><br/>
Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells.  [electronic resource] 

 -  The Journal of biological chemistry  Dec 2003 
 - 50624-34 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0021-9258 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M309011200  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Apoptosis<br/>Blotting, Western<br/>Caspase 8<br/>Caspase 9<br/>Caspases--metabolism<br/>Cell Death<br/>Cell Line<br/>Cell Line, Tumor<br/>Cytochromes c--metabolism<br/>Cytosol--metabolism<br/>Down-Regulation<br/>Enzyme Activation<br/>Enzyme Inhibitors--pharmacology<br/>Flow Cytometry<br/>Humans<br/>Jurkat Cells<br/>Membrane Potentials<br/>Microscopy, Fluorescence<br/>Mitochondria--metabolism<br/>Mitogen-Activated Protein Kinase 1--metabolism<br/>Mitogen-Activated Protein Kinase 3<br/>Mitogen-Activated Protein Kinases--metabolism<br/>Models, Biological<br/>Phosphorylation<br/>Plasmids--metabolism<br/>Protein Transport<br/>Proto-Oncogene Proteins--metabolism<br/>Proto-Oncogene Proteins c-bcl-2<br/>Sphingosine--analogs & derivatives<br/>Tetradecanoylphorbol Acetate--pharmacology<br/>Time Factors<br/>bcl-2-Associated X Protein<br/>p38 Mitogen-Activated Protein Kinases