Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration. [electronic resource]
- The European journal of neuroscience Sep 2003
- 1387-401 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
0953-816X
10.1046/j.1460-9568.2003.02864.x doi
1-Methyl-4-phenylpyridinium--toxicity Animals Apoptosis--drug effects Benzimidazoles--metabolism Caspase 3 Caspase 9 Caspase Inhibitors Caspases--metabolism Cell Line Coumarins--metabolism Cytochromes c--metabolism DNA Fragmentation Dopamine--metabolism Dose-Response Relationship, Drug Drug Interactions Enzyme Inhibitors--pharmacology Flow Cytometry--instrumentation Free Radical Scavengers--pharmacology Gene Expression--drug effects Herbicides--toxicity In Vitro Techniques Manganese Compounds--pharmacology Mesencephalon--cytology Metalloporphyrins--pharmacology Nerve Degeneration--chemically induced Organometallic Compounds Oxidative Stress--drug effects Precipitin Tests Protein Kinase C--classification Protein Kinase C-delta Rats Reactive Oxygen Species--metabolism Time Factors Transfection--methods