M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase. [electronic resource]
- Cell death and differentiation Oct 2003
- 1165-77 p. digital
Publication Type: Journal Article
1350-9047
10.1038/sj.cdd.4401285 doi
Acid Phosphatase--metabolism Actins--metabolism Adaptor Proteins, Signal Transducing Alendronate--pharmacology Alkyl and Aryl Transferases--antagonists & inhibitors Animals Apoptosis--drug effects Blotting, Western Bone Marrow Cells--cytology Bone Resorption--metabolism Carrier Proteins--metabolism Caspase 3 Caspase 9 Caspases--metabolism Cell Cycle Proteins Cell Survival--drug effects Collagen--metabolism Collagen Type I Cytokines--pharmacology Diterpenes--pharmacology Enzyme Inhibitors--pharmacology Eukaryotic Initiation Factors Immunohistochemistry Interleukin-1--pharmacology Isoenzymes--metabolism Macrophage Colony-Stimulating Factor--pharmacology Membrane Glycoproteins--pharmacology Mice Models, Biological NF-kappa B--analysis Osteoclasts--cytology Peptides--metabolism Phosphoproteins--metabolism Protein Kinases--physiology Protein Serine-Threonine Kinases--metabolism Protein Synthesis Inhibitors--pharmacology Proto-Oncogene Proteins--analysis Proto-Oncogene Proteins c-akt RANK Ligand Receptor Activator of Nuclear Factor-kappa B Ribosomal Protein S6--metabolism Ribosomal Protein S6 Kinases, 70-kDa--metabolism Serine-Threonine Kinase 3 Signal Transduction--physiology Sirolimus--pharmacology TOR Serine-Threonine Kinases Tartrate-Resistant Acid Phosphatase Tumor Necrosis Factor-alpha--pharmacology