TY - GEN AU - Goodkin,D E AU - Rudick,R A AU - VanderBrug Medendorp,S AU - Greene,T AU - Schwetz,K M AU - Fischer,J AU - Daughtry,M M AU - Ross,J AU - Van Dyke,C TI - Low-dose (7.5 mg) oral methotrexate for chronic progressive multiple sclerosis. Design of a randomized, placebo-controlled trial with sample size benefits from a composite outcome variable including preliminary data on toxicity SN - 1059-2725 PY - 1994///0317 KW - Adult KW - Central Nervous System KW - drug effects KW - Chronic Disease KW - Double-Blind Method KW - Drug Administration Schedule KW - Female KW - Humans KW - Male KW - Methotrexate KW - administration & dosage KW - Middle Aged KW - Multiple Sclerosis KW - drug therapy KW - Neuropsychological Tests KW - Outcome Assessment, Health Care KW - Research Design N1 - Publication Type: Clinical Trial; Journal Article; Randomized Controlled Trial ER -