Goodkin, D E <br/><br/>
Low-dose (7.5 mg) oral methotrexate for chronic progressive multiple sclerosis. Design of a randomized, placebo-controlled trial with sample size benefits from a composite outcome variable including preliminary data on toxicity.  [electronic resource] 

 -  The Online journal of current clinical trials  Sep 1992 
 - [7723 words; 89 paragraphs] p.  digital 
<br/><br/> Publication Type: Clinical Trial; Journal Article; Randomized Controlled Trial 
<br/><br/><label>ISSN: </label>1059-2725 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adult<br/>Central Nervous System--drug effects<br/>Chronic Disease<br/>Double-Blind Method<br/>Drug Administration Schedule<br/>Female<br/>Humans<br/>Male<br/>Methotrexate--administration & dosage<br/>Middle Aged<br/>Multiple Sclerosis--drug therapy<br/>Neuropsychological Tests<br/>Outcome Assessment, Health Care<br/>Research Design