Alava, M A

Increased intracellular cyclic AMP inhibits inositol phospholipid hydrolysis induced by perturbation of the T cell receptor/CD3 complex but not by G-protein stimulation. Association with protein kinase A-mediated phosphorylation of phospholipase C-gamma 1. [electronic resource] - The Biochemical journal May 1992 - 189-99 p. digital

Publication Type: Journal Article

0264-6021

10.1042/bj2840189 doi


Animals
Antigens, Differentiation, T-Lymphocyte--drug effects
CD3 Complex
Cattle
Cell Membrane Permeability--drug effects
Cholera Toxin--pharmacology
Colforsin--analogs & derivatives
Cricetinae
Cyclic AMP--biosynthesis
Dinoprostone--pharmacology
Diterpenes
Down-Regulation--physiology
Enzyme Activation
GTP-Binding Proteins--drug effects
Hydrolysis
Inositol Phosphates--metabolism
Intracellular Fluid--metabolism
Isoenzymes--metabolism
Mice
Mice, Nude
Phospholipids--metabolism
Phosphorylation
Protein Kinases--metabolism
Receptors, Antigen, T-Cell--antagonists & inhibitors
Stimulation, Chemical
T-Lymphocytes--drug effects
T-Lymphocytes, Helper-Inducer--drug effects
Type C Phospholipases--metabolism